Raws li cov nplaum nplaum rau cov ntsiav tshuaj thiab granules, nws tuaj yeem ua tiav los ntawm ntub, qhuav granulation, lossis ncaj qha ntsiav tshuaj nias txoj kev. Feem ntau, nws qhov ntau npaum li cas yog 2-5% ntawm tag nrho cov nyiaj ntawm kev npaj, feem ntau yog nyob ib ncig ntawm 3%, thiab qhov concentration ntawm cov nplaum feem ntau yog 5-10%. Raws li cov khoom sib txawv thiab excipients, dej, hexanol, isopropanol, thiab lwm yam tuaj yeem siv los ua cov kuab tshuaj. Thaum siv cov ntsiav tshuaj ncaj qha nias txoj kev, qhov ntau npaum li cas yog nyob ib ncig ntawm 5%. Lactose, sorbitol, mannitol, microcrystalline cellulose, thiab lwm yam tuaj yeem siv los ua cov khoom siv ntxiv, tab sis kev saib xyuas yuav tsum tau them rau kev tswj cov dej noo hauv cov khoom xyaw kom muaj kev sib haum xeeb.
Raws li cov txheej txheem zaj duab xis, cov khoom no feem ntau siv ua ke nrog cellulose derivatives, shellac, thiab siab molecular hnyav polyethylene glycol los txhim kho lub zog ntawm zaj duab xis, tswj nws yooj yim thiab solubility; Feem ntau, nws tsis tas yuav ntxiv ester plasticizers.
Thaum ua ntawv thov rau txheej txheej txheej txheej ntawm cov dej rhiab rau cov tshuaj cores, cov cores tuaj yeem ua kom sov rau {{0}} degree ua ntej, thiab tom qab ntawd txau nrog 10% cov tshuaj tsis muaj dej ntawm cov khoom (ethanol, isopropanol, ethyl acetate los yog acetone), nrog rau cov tshuaj txau ntawm 0.4mg / cm2.